FIG. 6.
Dietary and hormonal control of H2S in longevity regulation. DR stimulates endogenous H2S production directly through energy and nutrient sensing pathways and/or indirectly through suppression of GH and TH production and signaling. Inhibition of GH and TH signaling is sufficient to activate H2S production pathways, resulting in a positive feedback loop. H2S can act through multiple molecular-, cellular-, and organismal-level mechanisms to increase fitness and longevity. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars