Table 1.

Performances of static and dynamic serum CA125 test-based diagnostic criteria for early-stage ovarian cancer

Diagnostic criteria	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Youden’s index
CA125 alone
Random CA125 ≥ 35 U/mL	75.0	25.4	6.6	93.6	0.004
Fasting CA125 ≥ 35 U/mL	72.2	25.8	6.4	93.0	-0.020
Postprandial CA125 ≥ 35 U/mL	77.8	25.0	6.8	94.2	0.028
Random CA125 ≥ 20 U/mL	91.6	14.0	6.9	97.1	0.056
Fasting CA125 ≥ 20 U/mL	91.7	13.2	6.9	95.8	0.049
Postprandial CA125 ≥ 20 U/mL	94.4	13.0	7.1	96.0	0.075
CA125 postprandial increment alone
CA125 increment ≥ 10%	83.3	96.3	61.1	98.8	0.796
CA125 and postprandial increment combined
Fasting CA125 ≥ 20 U/mL and CA125 increment ≥ 10%	77.8	97.5	68.1	98.4	0.752
SVM-based CA125-increment algorithm
σ = 25, fasting CA125 and postprandial increment as inputs	91.7	99.2	89.2	99.4	0.924