Table 3.
Correlations between clinicopathologic findings and high DKK1 expression with ß-catenin positivity
| Clinicopathologic features | High DKK1 and positive ß-catenin | P-value | |
|---|---|---|---|
| Yes (%) 35 (22.2) |
No (%) 123 (77.8) |
||
| Age, years | |||
| > 62 | 21 (60.0) | 58 (47.2) | 0.180 |
| ≤ 62 | 14 (40.0) | 65 (52.8) | |
| Sex | |||
| Male | 27 (77.1) | 86 (69.9) | 0.403 |
| Female | 8 (22.9) | 37 (30.1) | |
| T stage | |||
| T2 /3 | 11 (31.4) | 31 (25.2) | 0.462 |
| T4 | 24 (68.6) | 92 (74.8) | |
| N stage | |||
| N0/1 | 14 (40.0) | 73 (59.3) | 0.042 |
| N2/3 | 21 (60.0) | 50 (40.7) | |
| Lauren’s classification | |||
| Diffuse type | 20 (57.1) | 85 (69.1) | 0.186 |
| Non-diffuse type | 15 (42.9) | 38 (30.9) | |
| Tumor grade | |||
| Well/moderate | 12 (34.3) | 34 (27.6) | 0.445 |
| Poor | 23 (65.7) | 89 (72.4) | |
| Lymphatic invasion | |||
| Yes | 28 (80.0) | 99 (80.5) | 0.949 |
| No | 7 (20.0) | 24 (19.5) | |
| Vascular invasion | |||
| Yes | 3 (8.6) | 9 (7.3) | 0.805 |
| No | 32 (91.4) | 114 (92.7) | |
| TNM stage | |||
| I/II | 14 (40.0) | 54 (43.9) | 0.681 |
| III/IV | 21 (60.0) | 69 (56.1) | |