Table 5.

Univariate and multivariate analyses of disease-free survival and overall survival using the Cox proportional hazards model for all patients

Characteristics	Univariate analysis of DFS			Multivariate analysis of DFS
	Hazard ratio	95% CI	p-value	Hazard ratio	95% CI	p-value
Age (> 62 vs. ≤62)	1.251	0.725 - 2.158	0.420
Sex (female vs male)	1.005	0.544 - 1.856	0.987
Advanced T stage (pT4 vs. pT2/3)	7.564	2.356 – 24.286	0.001	6.569	2.014 – 21.422	< 0.001
Advanced N stage (pN2/3 vs. pN0/1)	3.544	1.959 – 6.409	< 0.001	2.500	1.359 – 4.601	0.003
Lauren’s classification (diffuse vs. non-diffuse)	1.255	0.680 - 2.317	0.467
Venous invasion (yes vs. no)	1.940	0.771 - 4.883	0.159
Tumor grade (poor vs well to moderate)	1.172	0.626 – 2.197	0.619
Adjuvant chemotherapy (yes vs. no)	1.196	0.687– 2.083	0.526
High DKK1 and positive ß-catenin (yes vs. no)	2.512	1.430 – 4.413	0.001	2.357	1.291 - 4.306	0.005
	Univariate analysis of OS			Multivariate analysis of OS
	1.934	1.269 - 2.946	0.002	1.820	1.189-2.785	0.006
	0.656	0.403 - 1.069	0.091
	3.356	1.825 - 6.170	< 0.001	3.137	1.674 – 5.879	< 0.001
	2.174	1.431 - 3.302	< 0.001	1.661	1.074 – 2.568	0.023
	1.073	0.690 - 1.668	0.755
	1.763	0.852 - 3.649	0.126
	1.058	0.671 - 1.668	0.808
	0.898	0.596 - 1.355	0.610
	2.522	1.645 – 3.867	< 0.001	2.140	1.343 – 3.409	0.001