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. 2018 May 2;11:24. doi: 10.1186/s13041-018-0368-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Calcium currents evoked by wild type and mutant Cav3.1 and Cav3.2 channels in tsA-201 cells. (a) Current-voltage (I/V) relationship of wild type or mutant Cav3.1-GFP ∆CT (1851–1875) mutant channels (n = 10). Values are represented as means +/− S.E. The solid lines are fits with the Boltzmann equation. (b) Mean peak current density representation from wild type or mutant Cav3.1-GFP ∆CT (1851–1875) channels (P < 0.001, n = 10). Asterisks denote statistical significance relative to wild type (****P < 0.0001, Student’s t-test). (c) Current-voltage (I/V) relationship of wild type or mutant Cav3.2-GFP ∆CT (1860–1884) channels (n = 18–19). Values are represented as means +/− S.E. The solid lines are fits with the Boltzmann equation. (d) Mean peak current density representation from wild type or mutant Cav3.2-GFP ∆CT (1860–1884) channels (P < 0.001, n = 10). Asterisks denote statistical significance relative to wild type (****P < 0.0001, Student’s t-test)