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. 2018 Mar 28;118(8):1142–1151. doi: 10.1038/s41416-018-0041-x

Table 1.

Associations between MED7 mRNA expression and clinicopathological variables in the METABRIC cohort

Clinicopathological criteria MED7 mRNA expression χ2 (p-value)
Low (%) High (%)
Age at diagnosis (years)
  ≤50 251 (59.3) 172 (40.7) 17.35 (<0.00001)
  >50 723 (47.9) 787 (52.1)
Tumour size (cm)
  ≤2.0 423 (49.4) 434 (50.6) 0.36 (0.554)
  >2.0 558 (50.7) 542 (49.3)
Histological grade
  1 62 (36.5) 108 (63.5) 21.68 (<0.0001)
  2 374 (48.6) 396 (51.4)
  3 521 (54.8) 429 (45.2)
Tumour type
  Ductal 866 (51.0) 833 (49) 19.39 (0.001)
  Lobulara 62 (42.2) 85 (57.8)
  Medullary like 26 (81.2) 6 (18.8)
  Special typea 19 (38.8) 30 (61.2)
  Miscellaneous 12 (57.1) 9 (42.9)
NPI
  Good prognostic group 313 (46.0) 367 (54.0) 7.95 (0.019)
  Moderate prognostic group 580 (52.8) 519 (47.2)
  Poor prognostic group 104 (52.3) 95 (47.7)
PAM50 subtype
  Luminal A 297 (41.4) 421 (58.6) 165.80 (<0.00001)
  Luminal B 179 (36.7) 309 (63.3)
  Basal 242 (73.8) 86 (26.2)
  Her2 164 (68.3) 76 (31.7)
  Normal like 112 (56.6) 86 (43.4)
IntClustMemb
  IntClustMemb 1 62 (44.6) 77 (55.4) 120.96 (<0.00001)
  IntClustMemb 2 32 (44.4) 40 (55.6)
  IntClustMemb 3 107 (36.9) 183 (63.1)
  IntClustMemb 4 183 (53.4) 160 (46.6)
  IntClustMemb 5 117 (61.6) 73 (38.4)
  IntClustMemb 6 39 (45.9) 46 (54.1)
  IntClustMemb 7 106 (55.8) 84 (44.2)
  IntClustMemb 8 105 (35.1) 194 (64.9)
  IntClustMemb 9 77 (53.1) 68 (46.9)
  IntClustMemb 10 169 (75.1) 56 (24.9)
ER
  Negative 312 (71.2) 126 (28.8) 97.43 (<0.00001)
  Positive 665 (44.4) 832 (55.6)
PR
  Negative 566 (60.3) 373 (39.7) 69.69 (<0.00001)
  Positive 431 (41.5) 608 (58.5)
HER2
  Negative 844 (48.8) 887 (51.2) 15.03 (0.0001)
  Positive 153 (61.9) 94 (38.1)

Significant p-values are highlighted in bold