Table 1.
Associations between MED7 mRNA expression and clinicopathological variables in the METABRIC cohort
| Clinicopathological criteria | MED7 mRNA expression | χ2 (p-value) | |
|---|---|---|---|
| Low (%) | High (%) | ||
| Age at diagnosis (years) | |||
| ≤50 | 251 (59.3) | 172 (40.7) | 17.35 (<0.00001) |
| >50 | 723 (47.9) | 787 (52.1) | |
| Tumour size (cm) | |||
| ≤2.0 | 423 (49.4) | 434 (50.6) | 0.36 (0.554) |
| >2.0 | 558 (50.7) | 542 (49.3) | |
| Histological grade | |||
| 1 | 62 (36.5) | 108 (63.5) | 21.68 (<0.0001) |
| 2 | 374 (48.6) | 396 (51.4) | |
| 3 | 521 (54.8) | 429 (45.2) | |
| Tumour type | |||
| Ductal | 866 (51.0) | 833 (49) | 19.39 (0.001) |
| Lobulara | 62 (42.2) | 85 (57.8) | |
| Medullary like | 26 (81.2) | 6 (18.8) | |
| Special typea | 19 (38.8) | 30 (61.2) | |
| Miscellaneous | 12 (57.1) | 9 (42.9) | |
| NPI | |||
| Good prognostic group | 313 (46.0) | 367 (54.0) | 7.95 (0.019) |
| Moderate prognostic group | 580 (52.8) | 519 (47.2) | |
| Poor prognostic group | 104 (52.3) | 95 (47.7) | |
| PAM50 subtype | |||
| Luminal A | 297 (41.4) | 421 (58.6) | 165.80 (<0.00001) |
| Luminal B | 179 (36.7) | 309 (63.3) | |
| Basal | 242 (73.8) | 86 (26.2) | |
| Her2 | 164 (68.3) | 76 (31.7) | |
| Normal like | 112 (56.6) | 86 (43.4) | |
| IntClustMemb | |||
| IntClustMemb 1 | 62 (44.6) | 77 (55.4) | 120.96 (<0.00001) |
| IntClustMemb 2 | 32 (44.4) | 40 (55.6) | |
| IntClustMemb 3 | 107 (36.9) | 183 (63.1) | |
| IntClustMemb 4 | 183 (53.4) | 160 (46.6) | |
| IntClustMemb 5 | 117 (61.6) | 73 (38.4) | |
| IntClustMemb 6 | 39 (45.9) | 46 (54.1) | |
| IntClustMemb 7 | 106 (55.8) | 84 (44.2) | |
| IntClustMemb 8 | 105 (35.1) | 194 (64.9) | |
| IntClustMemb 9 | 77 (53.1) | 68 (46.9) | |
| IntClustMemb 10 | 169 (75.1) | 56 (24.9) | |
| ER | |||
| Negative | 312 (71.2) | 126 (28.8) | 97.43 (<0.00001) |
| Positive | 665 (44.4) | 832 (55.6) | |
| PR | |||
| Negative | 566 (60.3) | 373 (39.7) | 69.69 (<0.00001) |
| Positive | 431 (41.5) | 608 (58.5) | |
| HER2 | |||
| Negative | 844 (48.8) | 887 (51.2) | 15.03 (0.0001) |
| Positive | 153 (61.9) | 94 (38.1) | |
Significant p-values are highlighted in bold