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Schematic representation of glutamine metabolism and the compounds used in this study. IDH isocitrate dehydrogenase, IDHmt mutated IDH, D-2-HG D-2-hydroxyglutarate, α-KG α-ketoglutarate, GLS glutaminase, GDH glutamate dehydrogenase, NAD nicotinamide adenine dinucleotide, TCA tricarboxylic acid
