Fig. 2.

Glutaminase expression correlates to tumour grade but not to IDH1/2 mutation status. a Total score (intensity + percentage) of glutaminase expression. *p = 0.001 by one-way ANOVA with the LSD post-hoc analysis. **p < 0.0001 by independent-samples T test, grouping the high-grade and the low-grade cartilage tumours. b No difference between IDH1/2 mutant and IDH1/2 wildtype central tumours was observed. c ACT without expression of GLS, scored as percentage 0, intensity 0. d Grade II chondrosarcoma with medium expression of GLS, scored as percentage 2, intensity 2. e Grade III chondrosarcoma with high expression of GLS, percentage 4 intensity 3. Black bars represent 50 µm