Fig. 3.

The glutaminase inhibitor CB-839 inhibits chondrosarcoma cell viability. a Expression levels of glutaminase in ten chondrosarcoma cell lines and two controls. Glutaminase is higher expressed in chondrosarcoma cell lines compared to growth plate and articular cartilage. b Ten chondrosarcoma cell lines were treated for 72 h with CB-839, a glutaminase inhibitor. Sensitivity differed between the different cell lines. c Indicated cell lines were treated with 0, 20 or 200 nM CB-839 in the presence or absence of FBS. In the absence of FBS, all cell lines are more sensitive for inhibition with CB-839, especially the IDH1/2 mutant cell lines