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. 2018 Mar 2;118(8):1062–1073. doi: 10.1038/s41416-018-0025-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 5 — HDACi/DNMTi induces a significant downregulation of IRF4 and MYC expression. a Seven HMCLs were treated for 7 days with decitabine (DNMTi) and TSA during the last 24 h. Data are the MYC and IRF4 gene expression in treated HMCLs compared to the control (arbitrary signal = 100) assayed using real-time PCR. b Protein expression of MYC and IRF4 was assayed using flow cytometry in three HMCLs, namely XG7, XG12, and XG19