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. 2018 Apr 19;3(8):e120147. doi: 10.1172/jci.insight.120147

Figure 1. Endothelial function during and after preeclampsia.

Figure 1

Wire myography results showing relaxation induced by 3 μM acetylcholine (ACh) in precontracted (1 μM phenylephrine) endothelium-intact aortic rings from mothers (A) (60 days postpartum) after normal pregnancies and pregnancies affected by preeclampsia (PE) treated and untreated with PRAV and the offspring (B) (postnatal day 30) (n = 7–8 mice/experimental group). Effects of NO synthesis inhibitor L-NAME (100 μM) are also shown. Red squares represent the mean. The top row in A and B represents the response to L-NAME, and the bottom represents responses to ACh. Comparisons between groups were performed by ANOVA with Bonferroni’s post hoc test. *P < 0.05, different from control, same time point; #P < 0.05, different from prepregnancy. (C) Collagen I deposition in maternal aorta after normal pregnancies and pregnancies affected by PE (untreated and treated with PRAV) (n = 7–8 mice/experimental group). Increased collagen I deposition (green fluorescence), indicative of fibrosis, is observed in maternal aortas 60 days after PE. Pravastatin given during pregnancy prevented aortic fibrosis. Scale bar: 50 μm.