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. 2018 Apr 19;3(8):e99488. doi: 10.1172/jci.insight.99488

Figure 5. Antitumor activity of E7 TCR T cells against cervical cancer in an in vivo model.

Figure 5

NSG mice with 12-day subcutaneous tumors were treated with a single intravenous injection of E7 TCR T cells. The number of T cells is indicated in the key. (A and B) 4050 or (C and D) CaSki human cervical cancer tumors were treated. In B and D, 198,000 IU systemic IL-2 was given daily by intraperitoneal injection for 3 days. The tumor area (product of the longest perpendicular diameters) is plotted on the y axis. Time after T cell injection is plotted on the x axis. The mean values from each group are plotted. Error bars represent the SEM (n = 5 mice per group). The results are representative of 2 independent experiments. UT, untransduced T cells; E7 TCR, E7 TCR–transduced T cells.