Figure 3. DHTKD1 expression in EoE.

Heatmap from RNA sequencing of patient esophageal biopsies showing log₂ fragments per kilobase of transcript per million mapped reads (FPKM) values for dehydrogenase E1 and transketolase domain–containing 1 (DHTKD1) expression in normal controls (NL, n = 6; open squares), unrelated patients with active eosinophilic esophagitis (EoE) (n = 8, shaded circles), and select, affected individuals from family 443 (boxed with dashed line): I.1 and II.1 (active disease, shaded triangle) and II.2 (inactive disease, open triangle) (A). Data are plotted by FPKM in a profile plot below in A and clustered in B; bars in B represent the mean ± SD. Statistical analysis was performed using one-way ANOVA (and nonparametric) with Dunn’s multiple comparisons test. *P < 0.05 and **P < 0.01 compared with NL unless otherwise noted.