Table 2.

Associations of the genetic risk score with CHD by ethnicity.

		African Americans		Latinos		Japanese Americans
CHD Risk Score(Mean ± SD, p)		Case = 67.67 ± 4.63Control = 67.03 ± 4.73p* = 4.4 × 10−5		Case = 69.05 ± 5.13Control = 68.37 ± 5.11p* = 4.5 × 10−7		Case = 70.44 ± 4.60Control = 70.26 ± 4.61p* = 0.28
Unweighted risk score		OR†	p†	ORb	p†	OR†	p†
	Continuous	1.031	4.09E-5	1.031	2.23E-8	1.014	0.11
	Quartile 1	Reference		Reference		Reference
	Quartile 2	1.084	0.42	1.048	0.55	1.001	0.99
	Quartile 3	1.132	0.21	1.190	0.03	1.288	0.02
	Quartile 4	1.397	6.39E-4	1.393	1.98E-5	1.093	0.42
Modified risk score I‡	Continuous	1.028	2.12E-4	1.022	5.27E-5	1.009	0.29
	Quartile 1	Reference		Reference		Reference
	Quartile 2	1.033	0.75	1.085	0.30	1.107	0.36
	Quartile 3	1.252	0.02	1.205	0.02	1.214	0.08
	Quartile 4	1.285	0.01	1.263	0.003	1.081	0.48
Modified risk score II§	Continuous	1.018	1.71E-3	1.028	9.06E-8	1.016	0.045
	Quartile 1	Reference		Reference		Reference
	Quartile 2	0.976	0.81	1.066	0.42	1.062	0.59
	Quartile 3	1.278	0.01	1.182	0.03	1.342	0.007
	Quartile 4	1.280	0.01	1.393	2.0E-5	1.175	0.15

^*Two-sided t-test

^†Logistic regression model adjusted for age, gender, BMI, and the first 10 principal components

^‡Risk score that includes ethnic-specific regional leading SNPs

^§Risk score that includes cross-ethnic regional leading SNPs