Table 3.
Levels of metabolites comparing different subject groups at pre- and post-intervention conditions
| Brain region | Metabolite ratio | Time | Migraine without aura (n=15) | Cervicogenic headache (n=15) | Healthy control (n=14) |
|---|---|---|---|---|---|
| Left thalamus | NAA/Cr | 1 | 1.91±0.22 | 1.94±0.27 | 2.36±0.36 |
| 2 | 2.11±0.35 | 1.86±0.20 | 2.35±0.41 | ||
| Statistics T(P) | 3.43 (0.006)* | –1.49 (0.160) | –0.11 (0.913) | ||
| Cho/Cr | 1 | 1.00±0.08 | 1.08±0.09 | 0.95±0.16 | |
| 2 | 1.05±0.13 | 1.01±0.06 | 1.04±0.13 | ||
| Statistics T(P) | 1.63 (0.132) | –2.11 (0.068) | 1.69 (0.116) | ||
| Cho/NAA | 1 | 0.52±0.08 | 0.58±0.09 | 0.41±0.08 | |
| 2 | 0.51±0.10 | 0.57±0.08 | 0.45±0.08 | ||
| Statistics T(P) | –1.00 (0.340) | –0.73 (0.488) | 1.96 (0.072) | ||
| Right thalamus | NAA/Cr | 1 | 1.83±0.18 | 1.82±0.18 | 2.19±0.20 |
| 2 | 1.96±0.14 | 1.78±0.15 | 2.12±0.31 | ||
| Statistics T(P) | 3.38 (0.006)* | –1.18 (0.256) | –0.88 (0.395) | ||
| Cho/Cr | 1 | 1.00±0.07 | 1.08±0.06 | 0.98±0.14 | |
| 2 | 1.04±0.10 | 1.04±0.07 | 1.01±0.09 | ||
| Statistics T(P) | 1.59 (0.140) | –1.83 (0.104) | 0.70 (0.497) | ||
| Cho/NAA | 1 | 0.55±0.06 | 0.60±0.07 | 0.45±0.06 | |
| 2 | 0.53±0.06 | 0.59±0.06 | 0.48±0.05 | ||
| Statistics T(P) | –1.06 (0.311) | –1.23 (0.292) | 1.84 (0.089) | ||
| Anterior cingulate cortex | NAA/Cr | 1 | 1.51±0.15 | 1.51±0.11 | 1.55±0.15 |
| 2 | 1.51±0.13 | 1.41±0.13 | 1.66±0.09 | ||
| Statistics T(P) | –0.12 (0.904) | –3.92 (0.002)* | 2.83 (0.014)* | ||
| Cho/Cr | 1 | 1.00±0.14 | 1.04±0.06 | 0.97±0.08 | |
| 2 | 1.05±0.13 | 1.06±0.08 | 0.95±0.08 | ||
| Statistics T(P) | 1.48 (0.168) | 0.79 (0.454) | –0.59 (0.565) | ||
| Cho/NAA | 1 | 0.67±0.12 | 0.69±0.05 | 0.62±0.09 | |
| 2 | 0.70±0.13 | 0.76±0.07 | 0.57±0.05 | ||
| Statistics T(P) | 1.32 (0.215) | 2.86 (0.021)* | –2.15 (0.051) | ||
| Posterior part of paracentral gyrus | NAA/Cr | 1 | 1.62±0.11 | 1.62±0.13 | 1.73±0.08 |
| 2 | 1.67±0.14 | 1.54±0.19 | 1.71±0.15 | ||
| Statistics T(P) | 1.64 (0.130) | –2.11 (0.067) | –0.53 (0.607) | ||
| Cho/Cr | 1 | 0.76±0.06 | 0.81±0.03 | 0.76±0.06 | |
| 2 | 0.79±0.07 | 0.78±0.06 | 0.78±0.08 | ||
| Statistics T(P) | 1.14 (0.280) | –1.51 (0.171) | 0.57 (0.577) | ||
| Cho/NAA | 1 | 0.50±0.08 | 0.50±0.03 | 0.44±0.03 | |
| 2 | 0.47±0.04 | 0.51±0.08 | 0.45±0.04 | ||
| Statistics T(P) | -0.92 (0.380) | 0.43 (0.676) | 1.43 (0.176) |
Note: 1=pre-intervention scan; 2=post-intervention scan;
*
p<0.05.
Abbreviations: NAA, N-acetylaspartate; Cr, creatine; Cho, choline-containing compounds; T, t-test; P, p-value.