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Fundus images, OCT, and FLA examinations showed a physiological phenotype in all BL/6J wild type control mice (left column). Most ApoE−/− had mild AMD-like alterations like DRS in fundus images and OCT (middle column red encircled). Those alterations could not be seen in FLA. NRF2−/− mice generally had a more severe AMD-like phenotype with many DRS and pigment alterations and even CNV formation in one eye (right column, red encircled).
