TABLE 3.

Change in LDL^a at 72 wk by treatment group, weight loss category at 72 wk and change in statin use at 72 wk

	OCA		Placebo
	72-wk change in LDL – mg/dL		72-wk change in LDL – mg/dL
	≥2% weight loss	<2% weight loss or Gain	≥2% weight loss	<2% weight loss or gain
Total
N	42	53	31	63
Mean change	19	3	−15	−2
No statin use at BL or wk 72
N	14	21	12	26
Mean change	14	7	−17	+2
Statin use at both BL and wk 72
N	18	22	11	27
Mean change	27	3	−20	+2
No statin use at BL; Statin use at wk 72
N	6	8	4	8
Mean change	−18	−16	−57	−30
Statin use at BL; No statin use at wk 72
N	4	2	1	2
Mean change	54	32	−8	+28

P-value = 0.66 from linear regression of change in LDL on interaction of treatment group and weight loss group with statin use group adjusted for baseline LDL.

^a7 OCA and 4 Placebo patients had missing values for calculated LDL due to high triglycerides.