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. Author manuscript; available in PMC: 2018 Jul 22.
Published in final edited form as: Nat Chem Biol. 2018 Jan 22;14(3):291–298. doi: 10.1038/nchembio.2556

Fig. 3. Pro-targets and anti-targets for LS1-15 identified through genetic screening.

Fig. 3

a, Examples of pro-targets (Eph, Src42A) and an anti-target (Lk6) of LS1-15 [4]. Error bars, standard errors in triplicate. Asterisks, p < 0.05 in Student’s t-test as compared with control.

b, Representative signaling and cellular pathways defined by pro-targets and anti-targets of 4. Shown are strong pro-targets and strong anti-targets giving > 91% and < 9% viability, respectively, as compared with ~50% viability of 4-treated control flies at 23°C. Human orthologs are indicated (parentheses). Full data is presented in Supplementary Tables 2 and 3, and Supplementary Fig. 5. Blue, anti-targets.