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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7689):511–514. doi: 10.1038/nature25186

Figure 3. Nt5c2R367Q decreases the intracellular purine nucleoside pool and increases secretion of purines in ALL cells.

Figure 3

Diagram of the purine de novo biosynthesis and salvage pathways, showing GC/MS and LC/MS/MS metabolic profiles (mass spectrometry scaled intensity, arbitrary units) of Nt5c2+/co-R367Q wild type and Nt5c2+/R367Q mutant isogenic primary murine T-ALL cells and their corresponding conditioned media (n=3 biological replicates). Box plots represent the upper quartile to lower quartile distribution. + Sign indicates mean value and horizontal line the median value. Whiskers indicate the maximum and minimum values.