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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7689):511–514. doi: 10.1038/nature25186

Extended Data Figure 4. NT5C2 R367Q expression displays fitness loss in T-ALL and B-ALL cell lines.

Extended Data Figure 4

Diagram of the purine de novo biosynthesis and salvage pathways, showing GC/MS and LC/MS/MS metabolic profiles (mass spectrometry scaled intensity, arbitrary units) of CUTLL1 and REH cell lines expressing wild type (WT) NT5C2 or NT5C2 p.R367Q and their corresponding conditioned media (n=3 biological replicates per sample). Box plots represent the upper quartile to lower quartile distribution. + Sign indicates mean value and horizontal line the median value. Whiskers indicate the maximum and minimum values of the distribution.