Extended Data Figure 5. NT5C2 mutations are late events ALL.

Integrated Sequential Network (ISN) illustrating the sequential order of somatic mutations in relapsed ALL by pooling evolutionary paths across patients. Each node represents a gene, and each arrow points from a gene with an early event to a gene with a late event. To test whether a gene within the ISN was significantly early or late, we used a one-sided binomial test based on in-degree and out-degree of each node.