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. Author manuscript; available in PMC: 2018 May 2.
Published in final edited form as: Sci Transl Med. 2017 Nov 29;9(418):eaam6764. doi: 10.1126/scitranslmed.aam6764

Table 1. Declined human kidney characteristics and experimental conditions.

Donor demographics, donor type; donation after brain death (DBD), donation after circulatory death (DCD), reason for decline, warm ischemic time, cold ischemic time, duration of ex vivo normothermic perfusion (NMP), mean renal blood flow (RBF), total urine output, macroscopic appearance, NPs, and time to administration of NPs.

Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Case 7 Case 8
Donor age (years) 57 25 44 68 45 64 65 57
Donor type (DBD/DCD) DCD DBD DCD DBD DBD DCD DCD DCD
Left/right kidney Left Right Right Right Left Left Left Left
Reason for decline Poor in situ perfusion Malignancy Suspected malignancy Suspected malignancy Poor in situ perfusion + prolonged agonal phase Suspected malignancy Histological changes consistent with diabetes Damage to ureter and artery
Warm ischemic time (min) 13 13 12 14 11
Cold ischemic time (hour:min) 13:13 17:17 34:37 16:03 22:38 27:05 18:20 25:58
NMP duration (hour:min) 4:30 6:50 5:45 5:00 5:00 8:30 8:30 8:30
Mean RBF (ml/min per 100 g) 88.0 ± 19.6 123.7 ± 35.2 91.6 ± 23.9 67.9 ± 31.7 83.5 ± 35.5 75.0 ± 22.1 77.3 ± 25.4 80.7 ± 37.7
Total urine output (ml) 177 730 107 1045 373 598 451 257
Macroscopic appearance Moderate Moderate Moderate Moderate Moderate Excellent Excellent Moderate
NP type CD31-NP Control-NP CD31-NP + Control-NP CD31-NP + Control-NP CD31-NP + Control-NP CD31-NP + Control-NP CD31-NP + Control-NP CD31-NP + Control-NP
NP circulating concentration 4 μg/ml 4 μg/ml 10 μg/ml 50 μg/ml 100 μg/ml 50 μg/ml 50 μg/ml 50 μg/ml
NP administration time (from start of perfusion) 30 min 50 min 45 min 75 min 60 min 30 min 30 min 30 min