Table 2. Functional characterization and histological analysis of kidneys 6 to 8.
The mean RBF, urine output, level of oxygen consumption, and perfusate pH levels at baseline (after 30 min of perfusion but before the administration of NPs), 2 hours, 4 hours, 6 hours, and 8 hours of perfusion. ATN, acute tubular necrosis.
| Case 6 | Case 7 | Case 8 | |
|---|---|---|---|
| RBF (ml/min per 100 g) | |||
| Baseline | 52 | 41 | 25 |
| 2 hours | 60 | 82 | 78 |
| 4 hours | 76 | 90 | 98 |
| 6 hours | 96 | 102 | 119 |
| 8 hours | 120 | 107 | 135 |
| Urine output (ml) | |||
| Baseline | 55 | 9 | 8 |
| 2 hours | 111 | 54 | 55 |
| 4 hours | 135 | 126 | 101 |
| 6 hours | 154 | 127 | 81 |
| 8 hours | 143 | 135 | 12 |
| Total | 598 | 451 | 257 |
| Oxygen consumption (ml/min per g) | |||
| Baseline | 38.5 | 46.0 | 57.9 |
| 2 hours | 43.9 | 61.0 | 56.6 |
| 4 hours | 52.2 | 67.4 | 70.9 |
| 6 hours | 70.2 | 75.8 | 52.1 |
| 8 hours | 84.7 | 81.0 | 99.4 |
| PH | |||
| Baseline | 7.21 | 7.23 | 7.34 |
| 2 hours | 7.27 | 7.41 | 7.35 |
| 4 hours | 7.34 | 7. 42 | 7.35 |
| 6 hours | 7.37 | 7.38 | 7.28 |
| 8 hours | 7.37 | 7.40 | 7.28 |
| Histology | |||
| Baseline | No ATN | No ATN | No ATN |
| 2 hours | No ATN | No ATN | No ATN |
| 4 hours | No ATN | No ATN | No ATN |
| 6 hours | No ATN | Focal mild ATN | No ATN |
| 8 hours | Focal mild ATN | No ATN | Focal mild ATN |