Table 2. Patient demographics and clinical characteristics.

Numbers of cases (%)	Development set (set 1; n = 656)			External validation set (set 2; n = 217)
	DIC (n = 228)	Non-DIC (n = 428)	P value	DIC (n = 80)	Non-DIC (n = 137)	P value
Age, years	60.8 ± 16.6	58.1 ± 17.5	.053	62.7 ± 15.9	64.2 ± 16.5	.228
Gender, male	119 (52.2)	225 (52.6)	.992	49 (61.3)	71 (51.8)	.530
Currently in ICU	155 (68.0)	171 (40.0)	< .001	59 (73.8)	59 (43.1)	< .001
APACHE II score ± SD *	30.2 ± 10.7	24.3 ± 9.8	< .001	25.3 ± 9.7	16.2 ± 6.7	< .001
Mortality (28-days)	146 (64.0)	77 (18.0)	< .001	53 (66.2)	12 (8.8)	< .001
On anticoagulation therapy	2 (0.9)	32 (7.5)	.001	2 (2.5)	5 (3.6)	.949
Thrombosis	12 (5.3)	46 (10.7)	.027	4 (5.0)	9 (6.6)	.862
Bleeding	60 (26.3)	85 (19.9)	.072	22 (27.5)	12 (8.8)	.001
Organ failure	116 (50.9)	58 (13.6)	< .001	39 (48.8)	15 (10.9)	< .001
SIRS score ≥ 3	176 (77.2)	146 (34.1)	< .001	66 (82.5)	53 (38.7)	< .001
Associated conditions with DIC
Sepsis/Infection	161 (70.6)	140 (32.7)	< .001	58 (72.5)	47 (34.3)	< .001
Tissue damage	28 (12.3)	51 (11.9)	.991	23 (28.7)	33 (24.1)	.551
Post major surgery	34 (14.9)	133 (31.1)	< .001	13 (16.2)	46 (33.6)	.009
Hematologic malignancy	26 (11.4)	35 (8.2)	.225	7 (8.8)	5 (3.6)	.201
Solid cancer	87 (38.2)	82 (19.2)	< .001	20 (25.0)	17 (12.4)	.028
Hepatic failure	34 (14.9)	17 (4.0)	< .001	13 (16.2)	4 (2.9)	.001
Obstetric complications	4 (1.8)	21 (4.9)	.073	1 (1.2)	3 (2.2)	> .999
Vascular abnormalities	4 (1.8)	18 (4.2)	.152	11 (13.8)	31 (22.6)	.156
Immunologic insult	4 (1.8)	22 (5.1)	.057	9 (11.2)	5 (3.6)	.056

* The Acute Physiology and Chronic Health Evaluation (APACHE) II score was calculated only if a patient was admitted to ICU.