Table 3. Laboratory results for full DIC profile parameters.
| Parameters, mean (SD) | Development set (set 1; n = 656) | External validation set (set 2; n = 217) | ||||
|---|---|---|---|---|---|---|
| DIC (n = 228) |
Non-DIC (n = 428) |
P value | DIC (n = 80) |
Non-DIC (n = 137) |
P value | |
| Global coagulation tests with DIC profile | ||||||
| Prothrombin time (PT; sec) | 21.9 (10.3) | 15.1 (6.5) | < .001 | 20.6 (7.4) | 14.6 (3.9) | < .001 |
| PT activity (%) | 50.4 (18.8) | 75.8 (20.9) | < .001 | 50.4 (17.9) | 77.7 (18.7) | < .001 |
| INR | 1.92 (0.90) | 1.32 (0.56) | < .001 | 1.72 (0.65) | 1.21 (0.34) | < .001 |
| aPTT (sec) | 60.3 (36.5) | 39.1 (18.8) | < .001 | 52.2 (35.6) | 31.3 (11.0) | < .001 |
| Thrombin time (sec) | 21.5 (17.0) | 20.0 (18.2) | .297 | 24.9 (13.9) | 19.3 (3.0) | < .001 |
| Fibrinogen (mg/dL) | 304 (189) | 415 (178) | < .001 | 326 (212) | 470 (202) | < .001 |
| D-dimer (μg/mL)a | 8.23 (12.95) | 2.10 (4.55) | < .001 | 16.96 (18.86) | 7.25 (12.16) | < .001 |
| Anti-thrombin III activity (%) | 53.8 (20.0) | 81.0 (24.6) | < .001 | 50.5 (19.9) | 79.8 (18.8) | < .001 |
| Fibrin degradation product (μg /mL) | 59.4 (62.3) | 18.0 (24.6) | < .001 | NAe | NA | NA |
| Protein C activity (%) | NA | NA | NA | 40.7 (19.5) | 81.9 (31.4) | < .001 |
| Complete blood count and related parameters | ||||||
| RBC count (×106/μL) | 2.97 (0.65) | 3.25 (0.69) | < .001 | 3.20 (0.89) | 3.56 (0.74) | .002 |
| Hemoglobin (g/dL) | 9.2 (2.0) | 10.0 (2.0) | < .001 | 9.9 (2.7) | 10.9 (2.0) | .003 |
| Hematocrit (%) | 27.5 (5.7) | 29.8 (5.9) | < .001 | 29.8 (8.1) | 33.0 (6.4) | .002 |
| MCV (fL) | 93.0 (6.8) | 92.3 (5.9) | .150 | 93.5 (6.3) | 92.9 (5.7) | .477 |
| MCH (pg) | 31.1 (2.3) | 30.8 (2.1) | .038 | 31.0 (2.4) | 30.7 (2.4) | .412 |
| MCHC (g/dL)b | 33.4 [32.4, 34.4] | 33.4 [32.5, 34.2] | .433 | 33.0 [32.1, 34.1] | 33.0 [32.4, 33.6] | .334 |
| RDW (%) | 16.5 (2.7) | 15.4 (2.4) | < .001 | 15.5 (2.8) | 14.1 (2.0) | < .001 |
| PLT count (×103/μL) | 57 (56) | 168 (129) | < .001 | 77 (78) | 211 (133) | < .001 |
| PLT changes (%/24hrs)c | -0.36 (0.60) | -0.15 (0.33) | < .001 | -0.40 (0.52) | -0.08 (0.32) | < .001 |
| PDW (%, fL)d | 61.9 (17.2) | 56.4 (10.6) | < .001 | 13.7 (3.7) | 11.5 (2.2) | < .001 |
| MPV (fL) | 10.45 (1.99) | 9.15 (1.49) | < .001 | 11.36 (1.99) | 10.33 (1.49) | < .001 |
| WBC count (×103/μL) | 12.75 (17.60) | 10.60 (9.61) | .044 | 11.75 (17.60) | 13.40 (9.61) | .218 |
| Differential count (%) | ||||||
| Neutrophil | 77.7 (24.0) | 75.5 (21.0) | .226 | 79.9 (15.4) | 78.0 (17.3) | .404 |
| Lymphocyte | 13.2 (19.3) | 14.4 (16.3) | .423 | 12.5 (15.4) | 13.5 (12.7) | .626 |
| Monocyte | 4.8 (3.6) | 5.5 (4.5) | .063 | 6.0 (4.4) | 7.0 (6.9) | .250 |
| Eosinophil | 0.8 (1.5) | 1.8 (3.8) | < .001 | 1.1 (1.8) | 1.3 (1.9) | .566 |
| Basophil | 0.2 (0.3) | 0.2 (0.2) | .845 | 0.4 (0.7) | 0.3 (0.3) | .114 |
| Large unstained cell (LUC) | 3.2 (13.0) | 2.2 (8.6) | .277 | NA | NA | NA |
| Delta neutrophil index (%) | 13.5 (16.2) | 5.0 (9.2) | < .001 | NA | NA | NA |
| Thrombotic microangiopathy score | 2.7 (1.5) | 2.0 (1.4) | < .001 | NA | NA | NA |
a measured in data display unit (DDU; set 1) or fibrinogen-equivalent unit (FEU; set 2). See Table A in S1 File.
b Non-parametric distribution, median [25, 75 percentiles].
c The percent change in PLT count within 24 hours was calculated only if previous PLT count was available.
d The report units are different for PDW value between set 1 (%) and set 2 (fL).
e NA, not applicable