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. 2018 May 2;7:76. doi: 10.1038/s41426-018-0075-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Phylogenetic trees based on the sequences of four partial of HEV ORF2 genes (CHN-SN-C2, CHN-SN-D2, CHN-SN-G2, and CHN-SN-R2) isolated in this study and other HEVs from various animal species. The trees were generated by the neighbor-joining method with bootstrap tests of 1000 replicates using the MEGA 7.0 software. b Viremia/fecal viral shedding, ALT levels, and antibody levels in rabbits experimentally infected with CaHEV. c Microscopic lesions in livers from negative control rabbits (left) and rabbits experimentally infected with CaHEV (right) showed lymphocytic venous periphlebitis (arrows). Liver sections were stained with hematoxylin and eosin