Table 2.
Association between genetic risk scores (GRSs) and incident CHD among GERA minority subjects.
| GRS_12 | GRS_51 | |
|---|---|---|
| African-Americans (n = 2,089) | ||
| Model 1a | 1.17 (0.98–1.40) | 1.11 (0.92–1.34) |
| Model 1b | 1.16 (0.97–1.39) | 1.09 (0.90–1.32) |
| Model 1c | 1.17 (0.97–1.40) | 1.09 (0.90–1.32) |
| Model 1d | 1.20 (1.00–1.44) | 1.14 (0.94–1.39) |
| Model 2a | ||
| Tertile 2 | 1.33 (0.82–2.17) | 1.14 (0.71–1.82) |
| Tertile 3 | 1.81 (1.14–2.88) | 1.42 (0.90–2.23) |
| Model 2b | ||
| Tertile 2 | 1.33 (0.81–2.18) | 1.06 (0.66–1.70) |
| Tertile 3 | 1.78 (1.12–2.83) | 1.34 (0.85–2.11) |
| Model 2c | ||
| Tertile 2 | 1.33 (0.82–2.18) | 1.06 (0.66–1.70) |
| Tertile 3 | 1.78 (1.12–2.84) | 1.34 (0.85–2.11) |
| Model 2d | ||
| Tertile 2 | 1.37 (0.82–2.29) | 1.04 (0.63–1.71) |
| Tertile 3 | 1.86 (1.15–3.01) | 1.49 (0.93–2.39) |
| Latinos (n = 4,349) | ||
| Model 1a | 1.18 (1.01–1.37) | 1.19 (1.02–1.39) |
| Model 1b | 1.23 (1.05–1.43) | 1.19 (1.02–1.39) |
| Model 1c | 1.23 (1.05–1.44) | 1.19 (1.02–1.38) |
| Model 1d | 1.19 (1.01–1.40) | 1.16 (0.99–1.36) |
| Model 2a | ||
| Tertile 2 | 0.94 (0.62–1.41) | 0.99 (0.65–1.48) |
| Tertile 3 | 1.59 (1.09–2.31) | 1.61 (1.12–2.34) |
| Model 2b | ||
| Tertile 2 | 0.89 (0.59–1.34) | 1.06 (0.70–1.60) |
| Tertile 3 | 1.68 (1.15–2.45) | 1.54 (1.06–2.24) |
| Model 2c | ||
| Tertile 2 | 0.88 (0.58–1.33) | 1.07 (0.71–1.62) |
| Tertile 3 | 1.68 (1.15–2.45) | 1.55 (1.07–2.25) |
| Model 2d | ||
| Tertile 2 | 0.89 (0.58–1.37) | 1.06 (0.69–1.62) |
| Tertile 3 | 1.52 (1.02–2.25) | 1.40 (0.95–2.06) |
| Asians (n = 4,804) | ||
| Model 1a | 1.09 (0.93–1.29) | 1.20 (1.02–1.41) |
| Model 1b | 1.10 (0.93–1.30) | 1.24 (1.05–1.46) |
| Model 1c | 1.10 (0.94–1.30) | 1.23 (1.04–1.46) |
| Model 1d | 1.07 (0.91–1.28) | 1.18 (0.99–1.40) |
| Model 2a | ||
| Tertile 2 | 0.87 (0.57–1.33) | 1.33 (0.87–2.03) |
| Tertile 3 | 1.19 (0.79–1.79) | 1.48 (0.98–2.25) |
| Model 2b | ||
| Tertile 2 | 0.95 (0.62–1.46) | 1.36 (0.89–2.09) |
| Tertile 3 | 1.27 (0.84–1.92) | 1.57 (1.04–2.39) |
| Model 2c | ||
| Tertile 2 | 0.96 (0.63–1.47) | 1.34 (0.88–2.06) |
| Tertile 3 | 1.27 (0.84–1.92) | 1.56 (1.02–2.36) |
| Model 2d | ||
| Tertile 2 | 1.01 (0.65–1.57) | 1.37 (0.88–2.12) |
| Tertile 3 | 1.19 (0.77–1.83) | 1.43 (0.93–2.22) |
| Fixed-effects Meta-analysis of All Minority Groups Combined (n = 11,242) | ||
| Model 1a | 1.15 (1.04–1.26) | 1.17 (1.06–1.29) |
| Model 1b | 1.17 (1.06–1.28) | 1.18 (1.07–1.30) |
| Model 1c | 1.17 (1.06–1.28) | 1.18 (1.07–1.30) |
| Model 1d | 1.15 (1.04–1.27) | 1.16 (1.05–1.28) |
| Model 2a | ||
| Tertile 2 | 1.00 (0.78–1.29) | 1.14 (0.89–1.47) |
| Tertile 3 | 1.49 (1.18–1.89) | 1.52 (1.20–1.92) |
| Model 2b | ||
| Tertile 2 | 1.01 (0.78–1.30) | 1.16 (0.90–1.49) |
| Tertile 3 | 1.55 (1.22–1.97) | 1.49 (1.18–1.89) |
| Model 2c | ||
| Tertile 2 | 1.01 (0.79–1.31) | 1.15 (0.90–1.48) |
| Tertile 3 | 1.55 (1.22–1.97) | 1.49 (1.18–1.89) |
| Model 2d | ||
| Tertile 2 | 1.04 (0.80–1.36) | 1.15 (0.89–1.50) |
| Tertile 3 | 1.48 (1.15–1.90) | 1.43 (1.12–1.84) |
CHD denotes coronary heart disease;
Table entries are hazard ratios (95% CI);
See Statistical Methods for explanation of Models 1a-1d and 2a-2d specifications.