Fig 2. Mycobactericidal activity of single 400 mg doses of bedaquiline in ex vivo whole blood culture (WBA) in healthy volunteers, alone (gray), or combined with either rifabutin 300 mg (RBT, red) or rifampin 600 mg (RIF, yellow), after 9 days of rifamycin dosing.

Panel A shows change in viability from beginning to end of each whole blood culture, expressed as log change per day of culture; panel B shows cumulative or total activity over the 12 hours following drug administration. Lines indicate mean values; shading indicates 90% confidence intervals.