Fig 3.

Relationship between drug concentration and whole blood bactericidal activity (WBA) for bedaquiline (panel A), rifampin (panel B), and rifabutin (panel C). Panels B and C also indicate activity of desacetyl rifamycin metabolites (open circles). All drug concentrations reflect those in whole blood culture. For bedaquiline, measured plasma concentrations were reduced by a factor of two to account for dilution with tissue culture medium in whole blood culture. Rifamycins and their metabolites were added directly to whole blood cultures at the indicated concentrations. Red triangles indicate plasma Cmax values, which have also been adjusted to account for dilution in whole blood culture. Vertical dotted lines indicate concentrations required for intracellular mycobacteriostasis (zero WBA).