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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Crit Rev Toxicol. 2017 Jul 18;47(10):811–844. doi: 10.1080/10408444.2017.1342598

Table 4.

Summary results of PE outcomes: exposure-effects and dose-effects reported in individual cohort studies

‘Exposure-effects’* ‘Dose-effects’
PE outcomes Overall BEI Low Med High Individual study results
Abnormal PE: (# positive groups/# tested): 46% (21/46) 0% (0/7) 40% (4/10) 20% (2/10) 79% (15/19) 92%  (12 of 13)

  Tremor: 41% (19/46) 0% 30% 10% 79% 83% (10 of 12)
  Motor Coordination: 22% (10/46) 0% 10% 10% 42% 80% (4 of 5)
  Deep Tendon Reflexes: 22% (10/46) 0% 0% 0% 53% 60% (3 of 5)
  Sensory Function: 11% (05/46) 0% 0% 0% 26% 75% (3 of 4)

Key: Table presents summary results of all cohort studies that performed PE; data from the nested case-control study by Albers et al (1982) is not included.

*

= The proportion of cohort study groups with positive findings (i.e. # with ≥ 1 positive findings divided by # of study groups evaluated).

= The proportion of cohort studies that reported positive dose-relatedness among those cohort studies that evaluated dose-relatedness.