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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Crit Rev Toxicol. 2017 Jul 18;47(10):811–844. doi: 10.1080/10408444.2017.1342598

TABLE 8.

Sensitivity analysis: summary of NB results, UHg, descriptive data, and Tier ratings across category of exposure

Exposure
Category
NB Results UHg (µg/L) in exposed Age (yrs) of exposed Number of workers Quality Tier
% with positive results* Mean (range) Mean (range) Exposed/Controls All (+)
Overall: 64% (18 of 28 groups) 110 (11 – 880) 38 (27–51) 1257/1092 1.5 1.6

  HIGH 100% (6 of 6 groups) 316 (235 – 880) 37 (35 – 51) 253/249 1.4 1.4

  MED 80% (4 of 5 groups) 134 (108 – 173) 36 (27– 47) 190/210 1.7 1.8

  LOW 60% (3 of 5 groups) 52 (50 –82) 35 (29 –51) 297/227 1.2 1.1

  < BEI 42% (5 of 12 groups) 23 (11 – 35) 40 (33–47) 511/471 1.6 1.9

Table summarizes data from 28 cohort study groups described in 25 cohort studies; data from Albers case-control study not included.

*

= The proportion of study groups with positive findings (i.e. # with ≥ 1 positive finding on NB testing, divided by # of study groups evaluated using NB tests.

= Weighted average of group means and (the range of means); calculated from data reported for individual study groups.

= When a study reported findings for multiple study groups, the total number of controls in that study was assigned to each study group if stratified into a separate exposure category (i.e. Gunther 1996, Soleo 1990, Tang 2006); thus the sum of controls listed across exposure categories does not agree with the Overall sum of controls.

= Average of Quality Tier value weighted by study group size (i.e. total number of exposed and controls)) for all study groups evaluated using NB testing, and those study groups with positive (+) results.