Table B1. Estimated drug treatment costs based on different package forms of the active substances.

Active substance	Large package form and strength of drug	Estimated treatment cost (large package)	Small package form and strength of drug	Estimated treatment cost (small package)
Bevacizumab	Concentrate for solution infusion 25mg/ml 16 ml	€51,836.10	Concentrate for solution infusion 25mg/ml 4 ml	€51,835.28
Bevacizumab	Injection fluid 25mg/ml 0.15 ml	€174,399.68	Injection fluid 25mg/ml 0.05 ml	€603,691.20
Capecitabin	Tablet 500 mg	€339.55	Tablet 150 mg	€1,131.84
Cyclophosphamide	Powder injection fluid 2000 mg	€227.25	Powder injection fluid 500 mg	€251.90
Docetaxel	Concentrate for solution infusion 10mg/ml 16 ml	€5,338.08	Concentrate for solution infusion 20mg/ml 1 ml	€2,865.98
Docetaxel	Concentrate for solution infusion 20mg/ml 8 ml	€5,264.81	Concentrate for solution infusion 10mg/ml 2 ml	€2,643.38
Doxorubicin	Concentrate for solution infusion 2mg/ml 25 ml	€641.65	Powder for solution infusion 50 mg	€6,354.32
Doxorubicin	Powder for solution infusion 50 mg	€6,354.32	Concentrate for solution infusion 2mg/ml 10 ml	€9,950.91
Doxorubicin	Injection fluid 2mg/ml 100 ml	€9,950.96	Injection fluid 2mg/ml 5 ml	€637.44
Epirubicin	Injection fluid 2mg/ml 100 ml	€1,561.51	Infusion fluid 2mg/ml 5 ml	€7,250.40
Epirubicin	Infusion fluid 2mg/ml 100 ml	€1,841.13	Injection fluid 2mg/ml 5 ml	€7,178.40
Eribulin	Injection fluid 0,44mg/ml 3 ml	€8,551.01	Injection fluid 0,44mg/ml 2ml	€8,550.85
Everolimus	Tablet 10 mg	€31,207.25	Tablet 0.25 mg	€16,888.38
Everolimus	Dispersible tablet 5 mg	€21,254.31	Dispersible tablet 0.25 mg	€14,217.53
Fluorouracil	Injection fluid 50mg/ml 100 ml	€4,136.00	Crème 50mg/g 15 g	€52.09
fluorouracil	Crème 50mg/g 15 g	€33.04	Injection fluid 50mg/ml 5 ml	€177.12
Fulvestrant	Injection fluid 50 mg/ml 5 ml	€5,490.16	Injection fluid 50 mg/ml 5 ml	€5,490.16
Gemcitabin	Powder for solution infusion 2000 mg	€1,824.52	Powder for solution infusion 200 mg	€2,603.36
Gemcitabin	Concentrate for solution infusion 100mg/ml 20 ml	€2,418.96	Concentrate for solution infusion 38 mg/ml 5.26 ml	€1,411.00
Gemcitabin	Infusion fluid 10mg/ml 220 ml	€2,277.94	Infusion fluid 10mg/ml 120 ml	€2,277.94
Goserelin Acetate	Implantation stick 10.8 mg	€865.92	Implantation stick 3,6 mg	€880.71
Ibandronic acid	Injection fluid 1mg/ml 3ml	€554.99	Injection fluid 1mg/ml 3ml	€851.38
Ibandronic acid	Tablet 150 mg	€0.26	Tablet 50 mg	€2.40
Lapatinib	Tablet 250 mg	€18,682.30	Tablet 250 mg	€28,023.45
Megestrol	Tablet 160 mg	€1,025.81	Tablet 160 mg	€1,025.81
Melphalan	Powder for solution infusion 50 mg	€985.34	Powder for solution infusion 50 mg	€4,138.43
Melphalan	Tablet 2 mg	€500.85	Tablet 2 mg	€2,103.58
Mitomycin C	Powder for injection fluid 40 mg	€207.01	Powder for injection fluid 2 mg	€451.49
Mitoxantrone Hydrochloride	Concentrate for solution infusion 2mg/ml 15 ml	€1,486.01	Concentrate for solution infusion 2mg/ml 5 ml	€1,434.06
Paclitaxel	Concentrate for solution infusion 6 mg/ml 100 ml	€6,152.86	Powder for solution infusion 100 mg	€4,629.23
Paclitaxel	Powder for solution infusion 100 mg	€8,024.00	Concentrate for solution infusion 6 mg/ml 5 ml	€2,849.28
Pamidronate disodium	Concentrate for solution infusion 9mg/ml 10 ml	€1,109.25	Concentrate for solution infusion 3mg/ml 5 ml	€1,384.41
Pamidronate disodium	Infusion fluid 0,18mg/ml 500 ml	€131.09	Infusion fluid 0,18mg/ml 500 ml	€131.09
Pertuzumab	Concentrate for solution infusion 30mg/ml 14 ml	€16,665.64	Concentrate for solution infusion 30mg/ml 14 ml	€16,665.64
Thiotepa	Powder for solution infusion 100 mg	€14,467.30	Powder for solution infusion 15 mg	€16,207.35
Trastuzumab	Injection fluid 120mg/ml 5 ml	€16,286.10	Injection fluid 120mg/ml 5 ml	€16,286.10
Trastuzumab	Powder for solution infusion 150 mg	€21,947.45	Powder for solution infusion 150 mg	€21,947.45
Trastuzumab emtansine	Powder for solution infusion 160 mg	€44,505.75	Powder for solution infusion 100 mg	€44,505.75
Vinblastin	Injection fluid 1mg/ml 10 ml	€10,175.00	Injection fluid 1mg/ml 10 ml	€3,092.64
Vincristine	Injection fluid 1mg/ml 2 ml	€517.39	Injection fluid 1mg/ml 1 ml	€517.41