Table 1.
Hemodynamic parameters and temperatures throughout protocol in rabbits presenting experimental acute respiratory distress syndrome and treated by gaseous lung protective ventilation (LPV) or total liquid ventilation (TLV), respectively
| Parameters and groups | Baseline | Conventional ventilation | LPV or TLV | |||
|---|---|---|---|---|---|---|
| 15 min | 90 min | 10 min | 60 min | 120 min | ||
| Esophageal temperature (°C) | ||||||
| LPV | 38.7 ± 0.5 | 38.1 ± 0.6 | 38.2 ± 0.4 | 38.2 ± 0.4 | 38.6 ± 0.4 | 38.6 ± 0.4 |
| TLV | 38.5 ± 0.8 | 38.0 ± 0.8 | 38.8 ± 0.5 | 32.6 ± 0.6* | 33.1 ± 0.3* | 33.2 ± 0.2* |
| Rectal temperature (°C) | ||||||
| LPV | 38.7 ± 0.5 | 38.1 ± 0.6 | 38.2 ± 0.4 | 38.3 ± 0.3 | 38.4 ± 0.3 | 38.4 ± 0.4 |
| TLV | 38.7 ± 0.5 | 37.8 ± 0.9 | 39.1 ± 0.4 | 34.8 ± 0.5* | 33.0 ± 0.2* | 33.0 ± 0.1* |
| Heart rate (beats/min) | ||||||
| LPV | 257 ± 18 | 233 ± 16 | 246 ± 17 | 255 ± 17 | 248 ± 15 | 253 ± 7 |
| TLV | 242 ± 17 | 242 ± 17 | 262 ± 15 | 171 ± 6* | 172 ± 6* | 165 ± 7* |
| Mean arterial blood pressure (mmHg) | ||||||
| LPV | 75 ± 7 | 74 ± 6 | 65 ± 6 | 67 ± 5 | 61 ± 4 | 56 ± 8 |
| TLV | 69 ± 5 | 73 ± 3 | 65 ± 5 | 69 ± 6 | 82 ± 6* | 74 ± 9* |
| Lung compliance (ml/kg/cmH2O) | ||||||
| LPV | 0.99 ± 0.11 | 0.59 ± 0.10 | 0.56 ± 0.09 | 0.78 ± 0.16 | 0.78 ± 0.16 | 0.65 ± 0.10 |
| TLV | 1.09 ± 0.18 | 0.61 ± 0.07 | 0.63 ± 0.09 | 0.74 ± 0.09 | 0.71 ± 0.07 | 0.67 ± 0.06 |
Statistical comparisons were only made for group effect but not among time points
n = 8 in each LPV and TLV group
*p < 0.05 versus LPV