Table 2.
Biochemical characteristics throughout protocol in rabbits presenting experimental acute respiratory distress syndrome and treated by gaseous lung protective ventilation (LPV) or total liquid ventilation (TLV), respectively
| Parameters and groups | Baseline | Conventional ventilation (t = 90 min) | LPV or TLV | |
|---|---|---|---|---|
| 30 min | 120 min | |||
| Arterial blood saturation (%) | ||||
| LPV | 100 ± 0 | 76 ± 4 | 62 ± 9 | 80 ± 5 |
| TLV | 100 ± 0 | 73 ± 3 | 83 ± 12 | 90 ± 2 |
| Arterial blood pH | ||||
| LPV | 7.36 ± 0.03 | 7.15 ± 0.06 | 7.14 ± 0.15 | 7.18 ± 0.05 |
| TLV | 7.35 ± 0.04 | 7.22 ± 0.02 | 7.17 ± 0.04 | 7.16 ± 0.04 |
| Arterial blood PaO2 (mmHg) | ||||
| LPV | 227 ± 29 | 41 ± 5 | 62 ± 9 | 52 ± 8 |
| TLV | 219 ± 38 | 51 ± 9 | 83 ± 12 | 62 ± 4 |
| Arterial blood PaO2/FiO2 (mmHg) | ||||
| LPV | 755 ± 97 | 41 ± 5 | 62 ± 9 | 52 ± 8 |
| TLV | 730 ± 150 | 51 ± 9 | 83 ± 12 | 62 ± 4 |
| Arterial blood PaCO2 (mmHg) | ||||
| LPV | 47 ± 3 | 70 ± 11 | 68 ± 7 | 67 ± 7 |
| TLV | 49 ± 6 | 72 ± 4 | 80 ± 5 | 79 ± 4 |
| Bicarbonate blood level (mmol/l) | ||||
| LPV | 28 ± 2 | 24 ± 2 | 23 ± 1 | 24 ± 2 |
| TLV | 28 ± 1 | 29 ± 2 | 30 ± 1* | 31 ± 2* |
Statistical comparisons were only made for group effect but not among time points
n = 8 in each LPV and TLV group; Fi02, inhaled fraction of oxygen
*p < 0.05 versus LPV