Fig. 7.

Increased CD47 parallels SRSF10 expression in CC. Analyses of CD47 mRNA levels in normal cervical tissues and CC in the published a Biewenga Cervix data set, b Pyeon Multi-cancer data set and c GSE9750. d Box plots comparing CD47 mRNA levels in HPV-negative CCs and HPV 16/18-positive CCs in the published Scotto Cervix dataset from Oncomine. e Representative photographs of CD47 immunoreactivity in normal tissue, CIN, and CCs in TMA (scale bar: 200 μm). f The constituent ratio of CD47 expression assessed by blinded IHC analyses in normal tissues, CINs and CCs indicated in Fig. 2e. g Representative photographs of the SRSF10 and CD47 immunoreactivity in the same samples (scale bar: 200 μm). h The correlation of CD47 and SRSF10 protein levels in CC. i–l A positive correlation between the expression levels of CD47 and SRSF10 was observed in four independent CC data sets. *P < 0.05; **P < 0.01; ***P < 0.001