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. 2018 May 2;8:6903. doi: 10.1038/s41598-018-25191-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Progenitor cell proliferation and neuroblast production are not different between WT and EAAC1^−/− mice. (A) The schematic diagram shows the experimental procedure used in this study. BrdU was intraperitoneally injected twice per day for 4 consecutive days from day 3 after sham surgery. Mice were killed on day 7. (B,C,F) Representative images reveal BrdU- (B) Ki67- (C) and DCX-labeled cells (F) in the hippocampal DG of young and aged mice (WT or EAAC1^−/−) at 7 days after sham surgery. The Ki67-expressing cells are indicated by an arrow. Scale bar = 100 μm. (D,E,G) The bar graph shows the number of BrdU- (D) Ki67- (E), and DCX-labeled cells (G) in the SGZ from young and aged mice (WT or EAAC1^−/−) at 7 days after sham surgery. Data are expressed as the mean + SEM; n = 6–10 from each group, ^#p < 0.05 versus young mice.