Table 1.
Biochemical characteristics of wild-type rats and Lamp2y/− rats at 8 weeks (n = 8/group).
| Characteristics | Wild-type rats (n = 8) | LAMP2-deficient rats (n = 8) | Fold change | p valuea |
|---|---|---|---|---|
| AST (IU/L) | 198 ± 9.6 | 1411 ± 103.7 | 7.13 | 0.012* |
| CK (IU/L) | 459 ± 14.7 | 646 ± 20.6 | 1.41 | <0.0001** |
| CK-MB (IU/L) | 2065 ± 302.1 | 1825 ± 226.1 | 0.88 | 0.543 |
| LDH-1 (IU/L) | 883 ± 100.1 | 850 ± 92.4 | 0.96 | 0.818 |
| LDH (IU/L) | 1635 ± 126.3 | 1527 ± 169.2 | 0.93 | 0.621 |
| HBDH(IU/L) | 933 ± 149.5 | 1048 ± 175.7 | 1.12 | 0.633 |
| troponin I(ng/ml) | 0.314 ± 0.06 | 5.820 ± 0.75 | 18.53 | <0.0001** |
| myoglobin(ng/m) | 17 ± 1.7 | 65 ± 7.5 | 3.82 | 0.012* |
| ALT (IU/L) | 28 ± 5.1 | 93 ± 19.3 | 3.32 | 0.009** |
| TP (g/L) | 68 ± 2.8 | 64 ± 3.1 | 0.94 | 0.301 |
| ALB (g/L) | 32 ± 1.0 | 29 ± 1.8 | 0.91 | 0.167 |
| TBIL(mg/dL) | 0.68 ± 0.33 | 0.73 ± 0.25 | 1.07 | 0.906 |
| ALP (IU/L) | 214 ± 37.9 | 476 ± 84.9 | 2.22 | 0.014* |
| TG(mmol/L) | 0.93 ± 0.52 | 0.81 ± 0.56 | 0.87 | 0.877 |
| GLU(mmol/L) | 5.32 ± 2.14 | 9.11 ± 1.57 | 1.71 | 0.053 |
| CHOL(mmol/L) | 2.51 ± 0.69 | 5.21 ± 0.98 | 2.07 | 0.041* |
| BU(mmol/L) | 5.1 ± 0.56 | 8.9 ± 2.26 | 1.74 | 0.149 |
| CRE(μmol/L) | 58 ± 5.3 | 42 ± 3.8 | 0.72 | 0.081 |
| UA(μmol/L) | 46 ± 5.6 | 70 ± 10.6 | 1.52 | 0.093 |
AST, aspartate aminotransferase; CK, creatine kinase; LDH, lactate dehydrogenase; CK-MB, MB isoenzyme of creatine kinase; HBDH, hydroxybutyrate dehydrogenase; ALT, alanine aminotransferase; TP, total protein; ALB, albumin; TBIL, total bilirubin; ALP, alkaline phosphatase; BU, blood urea; CRE, creatinine; UA, Uric acid. aStudent’s t-test for two groups. Mean ± SEM. *P < 0.05; **P < 0.01.