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. 2018 May 2;8:6947. doi: 10.1038/s41598-018-25170-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations between APD₉₀ and FPD in cardiac myocyte cultures following the I_to current blockade. Effect of 739.9 μmol/L 4-AP on APD₉₀ (a) and FPD (b) (Control: n = 4; 4-AP: n = 4). APD₉₀ and FPD differed significantly both among pacing rates (p < 0.05), but only FPD was affected by I_to blockade (p < 0.05, ordinary two-way ANOVA). Linear regression correlating APD₉₀ (c), APD₈₀ (d) and APD₇₀ (e) with FPD due to the IC₅₀ concentration activity of 4-AP (APD₉₀: r² = 0.76, slope = 0.81; APD₈₀: r² = 0.71, slope = 0.74; APD₇₀: r² = 0.38, slope = 0.56; p < 0.0001). (f) Superimposed raw traces obtained before and after gap junction blockade by carbenoxolone and the concurrent EGMs. The raw traces were obtained from the same electrode as indicated on the left. Mean ± SEM; ***p < 0.001; ****p < 0.0001.