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. 2018 May 2;9:1772. doi: 10.1038/s41467-018-04171-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Predicting the protective spectrum for a new vaccine (Con H3) of the influenza A/H3N2 strain by CE-BLAST. a Antigenic clustering results between HA epitopes of 679 influenza strains. Strains with identical HA epitopes as the new vaccine were marked in green and labeled as Con H3. The pink region shows the potential antigenically similar or cross-reactive strains to Con H3. The locations of the three strains inside the spectrum are marked in green, whereas the other four strains outside the spectrum are marked in blue. b Inhibition concentration for the seven tested strains with the monoclonal neutralization antibody derived from Con H3-immuned mice. IC 50 values were calculated by fitting