Treatment regimen. Cyclophosphamide was administered at 2.5 mg/kg daily for 7 days, followed by 1.5 mg/kg daily for 7 weeks. The dose of cyclophosphamide was adjusted for renal function as described in the Methods section. Prednisone was administered at 60 mg daily and tapered to 15 mg by week 5. Thereafter, prednisone was tapered by 2.5 mg monthly. Rituximab (arrows) was administered as 1000 mg i.v. doses separated by approximately 2 weeks, followed by 1 dose every 4 months. CYC, cyclophosphamide; IOR, induction of remission; MOR, maintenance of remission.