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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Mol Cancer Res. 2018 Mar 9;16(5):825–832. doi: 10.1158/1541-7786.MCR-17-0576

Figure 4. Targeting CREB pathway suppresses SCLC growth in vivo.

Figure 4

(A) SCLC cells were infected with GFP (Ctrl) or dnPKA vector and transplanted into syngeneic hosts. Tumors were harvested after 4 weeks and weighed. (B) Immunohistochemistry staining of the tumors from (A). Scale bars, 100 μm. Quantification of positive staining cells were shown on the right. (C) SCLC cells were transplanted into syngeneic hosts. H89 treatment was started 2 weeks after the transplantation for another 2 weeks, and then tumors were harvested and weighed.