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. 2018 Apr 26;9:266. doi: 10.3389/fneur.2018.00266

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Copyright © 2018 Ayana, Singh and Pati.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI network construction of dysregulated proteome coded by 3,290 genes. Only 994 out of 3,290 genes passed the threshold interaction score of 0.70. The second representative protein–protein interaction network of the top differentially expressed gene set (27 genes) showed 11 out of 27 proteins coded by differential expressed genes to be actively interacting with each other or with varied protein partners. Red: differentially expressed gene in the primary data set, green: interacting partner, edge indicates the source to target node strength. Combined interaction score > 0.70, No. of first level interactors = 20.