Table 1.
Itonic amplitude (pA) | mIPSC area (fC) | mIPSC Frequency (Hz) | ||||
---|---|---|---|---|---|---|
Baseline | Acute EtOH | Baseline | Acute EtOH | Baseline | Acute EtOH | |
Ctrl | 22.2 ± 0.9 | 36.6 ± 3.0† | 2995.3 ± 232.5 | 2705.1 ± 193.7 | 2.47 ± 0.18 | 2.54 ± 0.21 |
E/W | 8.5 ± 0.5 | 9.9 ± 0.7* | 2615.5 ± 276.5 | 2648.3 ± 211.7 | 2.56 ± 0.23 | 2.65 ± 0.21 |
Che + E/W | 18.9 ± 1.1 | 31.8 ± 1.7† | 2895.7 ± 254.6 | 2791.6 ± 305.9 | 2.36 ± 0.16 | 2.45 ± 0.15 |
Che | 20.8 ± 1.5 | 33.3 ± 2.2† | 2811.4 ± 297.9 | 2855.4 ± 224.1 | 2.49 ± 0.26 | 2.62 ± 0.24 |
PDBu + E/W | 6.1 ± 0.6 | 6.9 ± 0.6* | 2508.3 ± 226.2 | 2811.1 ± 297.9 | 2.28 ± 0.23 | 2.32 ± 0.23 |
PDBu | 13.1 ± 0.7 | 16.1 ± 0.8* | 2805.8 ± 258.2 | 2592.9 ± 232.5 | 2.45 ± 0.20 | 2.57 ± 0.18 |
H89 + E/W | 6.9 ± 0.5 | 7.6 ± 0.6* | 2682.0 ± 312.7 | 2772.3 ± 148.4 | 2.32 ± 0.16 | 2.43 ± 0.20 |
H89 | 20.0 ± 0.7 | 31.3 ± 1.8† | 2888.2 ± 208.5 | 2801.8 ± 225.0 | 2.60 ± 0.12 | 2.67 ± 0.17 |
Forskolin + E/W | 7.0 ± 0.8 | 8.2 ± 0.9* | 2662.5 ± 200.7 | 2504.7 ± 185.3 | 2.23 ± 0.18 | 2.35 ± 0.17 |
Forskolin | 20.9 ± 1.2 | 34.1 ± 1.7† | 2516.8 ± 150.2 | 2690.0 ± 219.5 | 2.16 ± 0.24 | 2.15 ± 0.17 |
n = 11–14 per group. †p < 0.001 vs. the pre-EtOH baseline value, *p < 0.001 vs. Ctrl group (two-way ANOVA with post hoc Holm-Sidak test).