Table 5.
Comparisons between the groups with high and low expression of hypoxia inducible factor (HIF)-1α regarding their general characteristics and aggressiveness markers of melanoma.
| Variable | HIF-1α high expression (n = 16) | HIF-1α non-high expression (n = 360) | p-Value |
|---|---|---|---|
| Age (years) | 62.3 (15) | 56.2 (15) | 0.61 |
| BMI (kg/m2) | 27.8 (4.7) | 27.3 (4.6) | 0.86 |
| Gender (% males) | 56% | 53% | 0.38 |
| Breslow index | 5.53 (4.8) | 1.53 (2.21) | 0.0001 |
| Ulceration | 44% | 16% | 0.0001 |
| Positive sentinel lymph | 40% | 10% | 0.0001 |
| Mitotic index (/mm2) | 6.44 (7.9) | 2.1 (3.8) | 0.01 |
| Clark index | 3.7 (0.79) | 2.9 (0.85) | 0.65 |
| Regression | 25% | 24% | 0.90 |
Bold fond indicates p < 0.05.