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. 2018 Apr 26;9:804. doi: 10.3389/fimmu.2018.00804

Table 1.

Myeloid C-type lectin receptors (CLRs) surveyed in this review.

Signaling module Common name Gene name Source of flexible signaling Signaling pathwaya Flexibility outcomeb
No immunoreceptor tyrosine-based activating motif (ITAM) or immunoreceptor tyrosine-based inhibitory motif (ITIM) DC-SIGN CD209 Homotetramerization LSP1–KSR1–CNK–Raf-1 Intrinsic (80)
Sensing self and non-self LSP1–IKKε–Bcl3 Inhibitory (113115)
KSR1–CNK–Raf-1 Activating (59, 110)
Heterologous modulation (?) Activating (148)
Raf-1–MEK Inhibitory (112)
Heterotrimerization DC-SIGN/MR/MDL-1 DNAX-activation protein 12 (DAP12) Activating (86)

ITAM
Inline graphic
MDL-1 CLEC5A Heterotrimerization DC-SIGN/MR/MDL-1 DAP12 Activating (86)
Mannose receptor (MR) MRC1 Heterotrimerization DC-SIGN/MR/MDL-1 DAP12 Activating (86)
Inhibitory ITAM Fc receptor γ (FcRγ)–Grb2−SHP-1 Inhibitory (12)
Dectin-2 CLEC6A, Clec4n Heterodimerization Dectin-2/MCL FcRγ–spleen tyrosine kinase (Syk)–NF-κB p65 Activating (85)
MCL CLEC4D Heterodimerization Mincle/MCL FcRγ–Syk Activating (8184)
Mincle CLEC4E Heterodimerization Mincle/MCL FcRγ–Syk Activating (8184)
Inhibitory ITAM FcRγ–Syk–SHP-1 Inhibitory (91, 92)
Sensing self Retarded Syk Inhibitory (104, 105)
FcRγ–Syk Activating (7, 100103)
Heterologous modulation FcRγ−Syk Activating (140, 141, 143)
FcRγ−Syk–PKB–Mdm2 Inhibitory (146)

hemITAM
Inline graphic
CLEC-2 CLEC1B Homodimerization Syk Intrinsic (75, 76)
DNGR-1 CLEC9A Motif context Syk Intrinsic (19, 6064)
Dectin-1 CLEC7A Subcellular location Syk Intrinsic (6770)
Ligand size-conditioned subcellular location Syk–MAPK–reactive oxygen species Intrinsic (7174)
Phosphatase association SHP-1–PTEN–FcRγ SHIP-1 Inhibitory (93, 94)
SHP-2–Syk Activating (95)
Heterologous modulation Syk Activating (124126)
PI3K–mTOR–HIF-1α Activating (130134)
Syk–Pyk2–ERK–SOCS-1 Inhibitory (128)

ITIM
Inline graphic
DCIR CLEC4A, Clec4a2 Activating ITIM IFNI–STAT1 SHP-2 hijacking (?) Activating (58)
Sensing self and non-self (?) Activating (57)
SHP-2/SHIP-1 Inhibitory (108, 109)

aDescribed in the indicated reference. In case it was not studied in depth, it might be incomplete.

bThis column indicates the inflammatory balance provided by each source of signaling flexibility. “Intrinsic” refers to specific responses triggered by particular CLRs.