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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Mol Cancer Ther. 2018 Feb 13;17(5):1003–1011. doi: 10.1158/1535-7163.MCT-17-0930

FIGURE 4.

FIGURE 4

Determination by IC50 of IMGN853 cytotoxicity compared to controls, ADC isotype and M9346A, in uterine serous carcinoma (USC). (A) High FRα expressing (2+) uterine serous cancer cell line harvested from a patient derived xenograft model. IMGN853 shows significantly lower IC50 when compared to ADC isotype control (2.7 fold decrease, p<0.05). (B) Uterine serous cancer cell lines with lower FRα, ARK20 (FRα=1+) and (C) ARK1 (FRα=0) show no difference in the IC50s of IMGN853 and ADC isotype control. M9346A antibody was inactive against these cell lines.