Table 1.
Comparison of baseline characteristics in derivation and validation groups
| Derivation (n = 957) | Validation (n = 186) | P-value | ||
|---|---|---|---|---|
| Clinical | Male gender (%) | 249 (26%) | 63 (34%) | 0.02 |
| Mean age – years (SD) | 39.6 (9.16) | 38.0 (9.95) | 0.03 | |
| Mean Body Mass Index (SD) | 22.4 (3.71) | 22.2 (3.34) | 0.45 | |
| Median months on ART (IQR) | 34 (18 – 60) | 27 (13 – 51) | <0.01 | |
| ART adherence <95% (%) | 526 (55%) | 128 (69%) | <0.01 | |
| Laboratory | Mean hemoglobin – g/dL (SD) | 13.2 (1.78) | 12.9 (1.92) | 0.02 |
| Median ALT – IU/L (IQR) | 23 (19 – 32) | 23 (16 – 32) | 0.08 | |
| Median ANC – ×103/µL (IQR) | 1.9 (1.43 – 2.60) | 1.8 (1.36 – 2.53) | 0.94 | |
| Mean CD4 – cells/µL (SD) | 499.9 (265.92) | 448.5 (263.76) | 0.02 | |
| Mean CD8 – cells/µL (SD) | 884.5 (384) | 908.5 (336.81) | 0.47 | |
| VL >1,000 copies/ml (%) | 90 (9.40%) | 21 (11.3%) | 0.43 | |
| Mean Creatinine – mg/dL (SD) | 0.69 (0.19) | 0.72 (0.17) | 0.02 | |
SD – standard deviation; IQR – interquartile range; ART – antiretroviral therapy; ALT – alanine transaminase; ANC – absolute neutrophil count; VL – viral load.