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. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: Trop Med Int Health. 2018 Mar 30;23(5):526–532. doi: 10.1111/tmi.13047

Table 2.

Risk factors for virologic failure and contribution to prediction tool

		Univariate analysis		Multivariate analysis		Score if factor present
		Crude OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value	Score if factor present
Clinical	Male gender	0.64 (0.37, 1.12)	0.12
	Age < 38 years	2.83 (1.74, 4.61)	<0.01	3.44 (2.01, 5.89)	<0.01	1
	Body Mass Index <18.5	0.73 (0.34, 1.56)	0.42
	ART duration >2.5 years	1.91 (1.21, 3.04)	0.01	2.98 (1.79, 4.96)	<0.01	1
	ART adherence <95%	2.05 (1.28, 3.27)	<0.01	1.76 (1.06, 2.94)	0.03	1
Laboratory	Hemoglobin <13 g/dL	3.00 (1.89, 4.77)	<0.01	2.76 (1.70, 4.50)	<0.01	1
	ALT >33 U/L	0.54 (0.29, 1.01)	0.05	0.64 (0.32, 1.25)	0.19
	ANC <1.3 ×10³/µL	2.10 (1.30, 3.38)	<0.01	2.50 (1.44, 4.23)	0.08
	CD4 <200 cells/µL	4.80 (2.88, 8.02)	<0.01	5.94 (3.27, 10.78)	<0.01	2
	CD8 >885cells/µL	1.72 (1.11, 2.66)	0.02	2.10 (1.28, 3.44)	0.01	1^*
	Creatinine > 0.69 mg/dL	0.56 (0.19, 1.64)	0.30

ART – antiretroviral therapy; ALT – alanine transaminase; ANC – absolute neutrophil count

^*

CD8 not included in score based prediction tool as CD4 served as proxy