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. Author manuscript; available in PMC: 2019 May 2.
Published in final edited form as: J Am Chem Soc. 2018 Apr 19;140(17):5743–5754. doi: 10.1021/jacs.8b01323

Figure 2.

Figure 2

(a) General organization of class IV lanthipeptide biosynthetic gene clusters (b) Alignment of the venezuelin (VenA) and streptocollin (StcA) precursor peptides with the precursor peptides of the clusters investigated in this study. Residues undergoing dehydration are highlighted in blue, cysteines involved in ring formation in orange. According to standard RiPP nomenclature, the first amino acid of the core peptide is designated as residue 1, while the last amino acid of the leader peptide is defined as residue −1. (c) Primary structures of venezuelin49 and streptocollin.56 Abu = aminobutyric acid.