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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Mol Cancer Res. 2018 Feb 5;16(5):777–790. doi: 10.1158/1541-7786.MCR-17-0413

Fig. 2. AF treatment increases doxorubicin uptake in GBM xenografts.

Fig. 2

(A) Mice xenografted with GBM43 cells were given a combination of doxorubicin (Dox) and SPC diet or nasal AF. (B–D) Doxorubicin (red) and DAPI (blue) in tumors 20 min after tail-vein injection of doxorubicin. Scale bar: 40 μm. (E) Quantification of fluorescence (red) shows increased uptake of doxorubicin in tumor tissues of mice treated with SPC diet or nasal AF (n=3, **P < 0.01, one-way ANOVA). Kaplan-Meier (n=6 for control, n=5 for AF, and n=9 for SPC, **P < 0.01, ***P < 0.001; one-way ANOVA for control v/s AF and SPC, respectively) curve showing survival benefit following combination treatments with doxorubicin and SPC diet or nasal AF.